Cardiovascular dysautonomia in de novo Parkinson’s disease without orthostatic hypotension
Identifieur interne : 000375 ( Main/Exploration ); précédent : 000374; suivant : 000376Cardiovascular dysautonomia in de novo Parkinson’s disease without orthostatic hypotension
Auteurs : H. Oka [Japon] ; C. Toyoda [Japon] ; M. Yogo [Japon] ; S. Mochio [Japon]Source :
- European Journal of Neurology [ 1351-5101 ] ; 2011-02.
English descriptors
- KwdEn :
Abstract
Background: Clinical symptoms of Parkinson’s disease (PD) include not only motor distress, but also autonomic dysfunction. Objective: To study the characteristics of subclinical autonomic nervous dysfunction in de novo PD without orthostatic hypotension (OH). Methods: Autonomic nervous function including cardiac sympathetic gain was evaluated on the basis of cardiac radioiodinated metaiodobenzylguanidine (MIBG) uptake, the response to the Valsalva maneuver, and spectral analyses of the RR interval and blood pressure in 20 patients with de novo PD without OH. Results: Decreased cardiac MIBG uptake was found even in patients with PD without OH. Hemodynamic studies using the Valsalva maneuver revealed that patients with PD without OH had preserved baroreceptor reflex sensitivity in phase II and phase IV. Blood pressures normally responded in early and late phase II, but not in phase IV. Blood pressure recovery time was slightly reduced in patients with PD without OH when compared with the value in controls. The low frequency component of the RR interval and systolic blood pressure and the ratio of RR‐LF to RR‐HF in de novo PD without OH were significantly reduced when compared with the control values, whereas the high frequency component of the RR interval did not differ significantly. Conclusion: These results show that latent cardiac and vasomotor sympathetic dysfunction but not parasympathetic dysfunction is already present in early stage de novo PD, even without orthostatic hypotension.
Url:
DOI: 10.1111/j.1468-1331.2010.03135.x
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cardiovascular dysautonomia in de novo Parkinson’s disease without orthostatic hypotension</title><author><name sortKey="Oka, H" sort="Oka, H" uniqKey="Oka H" first="H." last="Oka">H. Oka</name></author><author><name sortKey="Toyoda, C" sort="Toyoda, C" uniqKey="Toyoda C" first="C." last="Toyoda">C. Toyoda</name></author><author><name sortKey="Yogo, M" sort="Yogo, M" uniqKey="Yogo M" first="M." last="Yogo">M. Yogo</name></author><author><name sortKey="Mochio, S" sort="Mochio, S" uniqKey="Mochio S" first="S." last="Mochio">S. Mochio</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:F5CC7202619088195278E5516D6B6109F5114210</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1111/j.1468-1331.2010.03135.x</idno><idno type="url">https://api.istex.fr/document/F5CC7202619088195278E5516D6B6109F5114210/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001161</idno><idno type="wicri:Area/Main/Curation">000F64</idno><idno type="wicri:Area/Main/Exploration">000375</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Cardiovascular dysautonomia in de novo Parkinson’s disease without orthostatic hypotension</title><author><name sortKey="Oka, H" sort="Oka, H" uniqKey="Oka H" first="H." last="Oka">H. Oka</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Daisan Hospital, The Jikei University School of Medicine, Izumihoncyo, Komae‐shi, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Toyoda, C" sort="Toyoda, C" uniqKey="Toyoda C" first="C." last="Toyoda">C. Toyoda</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Daisan Hospital, The Jikei University School of Medicine, Izumihoncyo, Komae‐shi, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Yogo, M" sort="Yogo, M" uniqKey="Yogo M" first="M." last="Yogo">M. Yogo</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Daisan Hospital, The Jikei University School of Medicine, Izumihoncyo, Komae‐shi, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Mochio, S" sort="Mochio, S" uniqKey="Mochio S" first="S." last="Mochio">S. Mochio</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Daisan Hospital, The Jikei University School of Medicine, Izumihoncyo, Komae‐shi, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neurology</title><idno type="ISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2011-02">2011-02</date><biblScope unit="volume">18</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="286">286</biblScope><biblScope unit="page" to="292">292</biblScope></imprint><idno type="ISSN">1351-5101</idno></series><idno type="istex">F5CC7202619088195278E5516D6B6109F5114210</idno><idno type="DOI">10.1111/j.1468-1331.2010.03135.x</idno><idno type="ArticleID">ENE3135</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1351-5101</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson’s disease</term><term>Valsalva maneuver</term><term>cardiac radioiodinated metaiodobenzylguanidine (123I‐MIBG) scintigraphy</term><term>cardiovascular sympathetic dysautonomia</term><term>orthostatic hypotension</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Clinical symptoms of Parkinson’s disease (PD) include not only motor distress, but also autonomic dysfunction. Objective: To study the characteristics of subclinical autonomic nervous dysfunction in de novo PD without orthostatic hypotension (OH). Methods: Autonomic nervous function including cardiac sympathetic gain was evaluated on the basis of cardiac radioiodinated metaiodobenzylguanidine (MIBG) uptake, the response to the Valsalva maneuver, and spectral analyses of the RR interval and blood pressure in 20 patients with de novo PD without OH. Results: Decreased cardiac MIBG uptake was found even in patients with PD without OH. Hemodynamic studies using the Valsalva maneuver revealed that patients with PD without OH had preserved baroreceptor reflex sensitivity in phase II and phase IV. Blood pressures normally responded in early and late phase II, but not in phase IV. Blood pressure recovery time was slightly reduced in patients with PD without OH when compared with the value in controls. The low frequency component of the RR interval and systolic blood pressure and the ratio of RR‐LF to RR‐HF in de novo PD without OH were significantly reduced when compared with the control values, whereas the high frequency component of the RR interval did not differ significantly. Conclusion: These results show that latent cardiac and vasomotor sympathetic dysfunction but not parasympathetic dysfunction is already present in early stage de novo PD, even without orthostatic hypotension.</div></front></TEI><affiliations><list><country><li>Japon</li></country><settlement><li>Tokyo</li></settlement></list><tree><country name="Japon"><noRegion><name sortKey="Oka, H" sort="Oka, H" uniqKey="Oka H" first="H." last="Oka">H. Oka</name></noRegion><name sortKey="Mochio, S" sort="Mochio, S" uniqKey="Mochio S" first="S." last="Mochio">S. Mochio</name><name sortKey="Toyoda, C" sort="Toyoda, C" uniqKey="Toyoda C" first="C." last="Toyoda">C. Toyoda</name><name sortKey="Yogo, M" sort="Yogo, M" uniqKey="Yogo M" first="M." last="Yogo">M. Yogo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000375 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000375 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:F5CC7202619088195278E5516D6B6109F5114210
|texte= Cardiovascular dysautonomia in de novo Parkinson’s disease without orthostatic hypotension
}}
| This area was generated with Dilib version V0.6.23. |  |